منابع مشابه
Fatty Acid Synthesis in Human Adipose Tissue*
The concentration of enzymes required for fatty acid synthesis was considerably less in extracts prepared from human omental adipose tissue than from rat epididymal fat. Overall rates of synthesis as measured by the incorporation of radioactive precursors into fatty acids were also much lower in human adipose tissue. The most striking difference was found with citrate-1,5-W, human adipose tissu...
متن کاملFatty acid synthesis by human adipose tissue.
The effect of age and nutritional status on the synthesis of fatty acids from a variety of labeled substrates by human adipose tissue in vitro was investigated. The results of this study clearly demonstrate that, although human adipose tissue is able to oxidize glucose to CO2, its ability to incorporate glucose-carbon into long chain fatty acids is negligible. Although the utilization of acetat...
متن کاملThe regulation of fatty acid synthesis in human skin fibroblasts. Inhibition of fatty acid synthesis by free fatty acids.
The short term regulation of fatty acid biosynthesis has been studied using primary cultures of human shin fibroblasts. These cells show rapid changes in rates of acetate incorporation into fatty acids depending upon the lipid content of the medium. When cells are incubated in medium containing lipid-deficient fetal calf serum overnight and then are switched to Eagle’s minimum essential medium,...
متن کاملFatty acid synthesis is a therapeutic target in human liposarcoma.
Liposarcomas (LS) are mesenchymal tumors that can recur after surgical resection and often do not respond to presently available medical therapies. This study demonstrates the dependence of LS on de novo long-chain fatty acid synthesis for growth. Lipogenesis can be impaired by inhibiting the activities of lipogenic enzymes, including acetyl CoA-carboxylase (ACC) and fatty acid synthase (FASN),...
متن کاملFatty acid synthesis from acetate by human liver homogenate fractions.
Evidence obtained during the last few years has shown that fatty acid synthesis in a variety of mammalian tissues (1-4) as well as in yeast (5, 6) and bacteria (7, 8) is not simply the reverse of fatty acid oxidation. This is borne out by the finding that oxidative processes seem to be confined to the mitochondrial portion of the cell, whereas fatty acid synthesis apparently occurs in extramito...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1966
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.20-1122